4-Chlorobenzenesulfonyl chloride → Benzenesulfonamide, 4-chloro-N-(2-hydroxyethyl)-N-methyl-

HRID 1834347ノート

反応式

HRID 1834347 の反応式
[CH3:1][NH:2][CH2:3][CH2:4][OH:5].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([S:13](Cl)(=[O:15])=[O:14])=[CH:9][CH:8]=1>O1CCCC1>[CH3:1][N:2]([CH2:3][CH2:4][OH:5])[S:13]([C:10]1[CH:11]=[CH:12][C:7]([Cl:6])=[CH:8][CH:9]=1)(=[O:15])=[O:14]

参加物

4

反応物 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 80162-(Methylamino)ethanol

生成物 1

HCID 108691Benzenesulfonamide, 4-chloro-N-(2-hydroxyethyl)-N-methyl-

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
50 °C

実験手順

To 20 parts of tetrahydrofuran is added 3.9 parts of N-methyl-ethanolamine. To this solution, 10 parts of tetrahydrofuran containing 5 parts of p-chlorobenzenesulfonyl chloride is added with stirring. After completion of the addition, the resultant mixture is stirred as it is for a while, and then heated for about 1 hour on a water bath at 50° C to terminate the reaction. Then, the salt is removed by filtration, and the filtrate is freed from the solvent, whereby an oily substance is obtained. This oily substance is subjected to distillation under reduced pressure to obtain 4.2 parts of a distillate, b.p. 180° C/0.5 mmHg.

後処理

  1. additionAfter completion of the addition
  2. customto terminate
  3. customthe reaction
  4. customThen, the salt is removed by filtration
  5. customis obtained
  6. distillationThis oily substance is subjected to distillation under reduced pressure
  7. customto obtain 4.2 parts of a distillate, b.p. 180° C/0.5 mmHg

出典と根拠

ORDレコード
ord-06267d990e584ad2911a17af6d3186b2
出典データセット
uspto-grants-1978_01
特許番号
US04070176

反応ノート

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