Methanesulfonyl chloride → N-(3-bromopropyl)methanesulfonamide

HRID 1834742ノート

反応式

HRID 1834742 の反応式
[BrH:1].Br[CH:3]([CH3:6])[CH2:4][NH2:5].[CH3:7][S:8](Cl)(=[O:10])=[O:9]>N1C=CC=CC=1.CCOCC>[Br:1][CH2:6][CH2:3][CH2:4][NH:5][S:8]([CH3:7])(=[O:10])=[O:9]

参加物

5

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 125707032-Bromopropan-1-amine hydrobromide

生成物 1

HCID 11218181N-(3-bromopropyl)methanesulfonamide

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 3283Diethyl Ether溶媒

実験手順

To a cooled solution of 2-bromopropylamine hydrobromide (43.8 g., 0.20 mole) in pyridine (100 ml.) was added over a period of 40 minutes methanesulfonyl chloride (15.2 ml., 0.20 mole). The reaction mixture was stirred for 15 minutes and then diluted with ether. The remaining solid was filtered off, washed with about 200 ml. of acetone. The filtrate and washes were concentrated in vacuo. The residue was extracted with three 100 ml. portions of acetone. Upon evaporation of the acetone, 30.4 g. of a thick oil representing the title compound. The product was confirmed by infrared analysis and nuclear magnetic resonance.

後処理

  1. filtrationThe remaining solid was filtered off
  2. washwashed with about 200 ml
  3. concentrationThe filtrate and washes were concentrated in vacuo
  4. extractionThe residue was extracted with three 100 ml
  5. customUpon evaporation of the acetone, 30.4 g

出典と根拠

ORDレコード
ord-31ac925bd9af4c86ba97b5b50aa47f26
出典データセット
uspto-grants-1978_01
特許番号
US04071350

反応ノート

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