Water → 5-Fluoro-4-hydroxy-2-oxo-N-(propan-2-yl)pyrimidine-1(2H)-carboximidic acid

HRID 1834765ノート

反応式

HRID 1834765 の反応式
[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[CH:10]([N:13]=[C:14]=[O:15])([CH3:12])[CH3:11].O>CS(C)=O>[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[N:6]([C:14](=[O:15])[NH:13][CH:10]([CH3:12])[CH3:11])[CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 33855-FluorouracilHCID 61277Isopropyl isocyanate

生成物 1

HCID 1515285-Fluoro-4-hydroxy-2-oxo-N-(propan-2-yl)pyrimidine-1(2H)-carboximidic acid収率 68.5%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

13.0g (0.1 mole) of 5-fluorouracil was dissolved in 100ml of dimethyl sulfoxide, then 9.4g (0.11mole) of isopropyl isocyanate was added thereto at room temperature and stirred at the same temperature for 15 hours. The reaction mixture was poured into 800ml of water. The resultant precipitate was filtered off, washed with water and dried to give 14.7g (68.5% yield) of 5-fluoro-1-(iso-propylcarbamoyl)-uracil melting at 275°-285° C (decomposition).

後処理

  1. filtrationThe resultant precipitate was filtered off
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-b42e7e17a7614223987f4a7a6da207d7
出典データセット
uspto-grants-1978_01
特許番号
US04071519

反応ノート

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