Isopropylamine → Methyl 5-oxo-1-(propan-2-yl)pyrrolidine-3-carboxylate

HRID 1834806ノート

反応式

HRID 1834806 の反応式
[CH:1]([NH2:4])([CH3:3])[CH3:2].[CH3:5][O:6][C:7](=[O:14])[C:8]([CH2:10][C:11](O)=[O:12])=[CH2:9]>C(OCC)C>[C:7]([CH:8]1[CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[C:11](=[O:12])[CH2:10]1)([O:6][CH3:5])=[O:14]

参加物

4

反応物 2

HCID 6363IsopropylamineHCID 4613903Butanedioic acid, 2-methylene-, methyl ester

生成物 1

HCID 20372066Methyl 5-oxo-1-(propan-2-yl)pyrrolidine-3-carboxylate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

In the course of 30 minutes, 59.1 g (1 mol) of isopropyl amine were added dropwise to 158 g (1 mol) of itaconic acid methyl ester in 120 ml of diethyl ether. When the slightly exothermic reaction had finished, the reaction mixture was allowed to stand for 24 hours at room temperature. Then the solvent was removed in vacuo and the residue was subjected to fractionated vacuum distillation. boiling point: 95-98° C/0.05 mm Hg; nD20 : 1.4680

後処理

  1. customWhen the slightly exothermic reaction
  2. customThen the solvent was removed in vacuo
  3. distillationthe residue was subjected to fractionated vacuum distillation

出典と根拠

ORDレコード
ord-301cc6f27425430e92edf203c395480a
出典データセット
uspto-grants-1978_01
特許番号
US04071530

反応ノート

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