N-(2-ethylthioethyl)-glycine tert-butyl ester → HCID 178477443、化合物

HRID 1834875ノート

反応式

HRID 1834875 の反応式
[C:1]([O:5][C:6](=[O:14])[CH2:7][NH:8][CH2:9][CH2:10][S:11][CH2:12][CH3:13])([CH3:4])([CH3:3])[CH3:2].[N:15]#[N:16].Cl.[CH3:18][O:19][C:20]1[CH:21]=[C:22]2[C:27](=[CH:28][C:29]=1[O:30][CH3:31])[CH:26]=[C:25]([S:32]([NH:35][C@H:36]([C:44](Cl)=[O:45])[CH2:37][CH2:38][CH2:39][NH:40][C:41](=[NH:43])[NH2:42])(=[O:34])=[O:33])[CH:24]=[CH:23]2>C(Cl)(Cl)Cl>[N:15]#[N:16].[C:1]([O:5][C:6](=[O:14])[CH2:7][N:8]([C:44](=[O:45])[C@H:36]([CH2:37][CH2:38][CH2:39][NH:40][C:41](=[NH:42])[NH2:43])[NH:35][S:32]([C:25]1[CH:24]=[CH:23][C:22]2[C:27](=[CH:28][C:29]([O:30][CH3:31])=[C:20]([O:19][CH3:18])[CH:21]=2)[CH:26]=1)(=[O:34])=[O:33])[CH2:9][CH2:10][S:11][CH2:12][CH3:13])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 20372345N-(2-ethylthioethyl)-glycine tert-butyl esterHCID 178486632HCID 178486632、化合物

生成物 1

HCID 178477443HCID 178477443、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a stirred solution of 4.80 g of N-(2-ethylthioethyl)-glycine tert-butyl ester in 40 ml of chloroform was carefully added N2 -(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl chloride hydrochloride obtained above. The reaction mixture was allowed to stand at room temperature overnight. The reaction mixture was washed twice with 20 ml of saturated sodium chloride solution and evaporated to dryness. The residue was triturated with a small amount of water to give a powder. This was collected by filtration and reprecipitated with ethanol-diethyl ether to give 5.00 g of N2 -(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl-N-(2-ethylthioethyl)glycine tert-butyl ester.

後処理

  1. customobtained above
  2. washThe reaction mixture was washed twice with 20 ml of saturated sodium chloride solution
  3. customevaporated to dryness
  4. customThe residue was triturated with a small amount of water
  5. customto give a powder
  6. filtrationThis was collected by filtration
  7. customreprecipitated with ethanol-diethyl ether

出典と根拠

ORDレコード
ord-071703dfd5f84a618b37b54da9ef0cd9
出典データセット
uspto-grants-1978_01
特許番号
US04071621

反応ノート

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