Isopropylamine → 2,6-Dihydro-2-methyl-6-(1-naphthalenylmethyl)-4-(2-propyl)amino-1H-pyrrolo[3,4-d]pyridazin-1-one
反応式
[CH:1]([NH2:4])([CH3:3])[CH3:2].Cl[C:6]1[C:7]2[C:8](=[CH:14][N:15]([CH2:17][C:18]3[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=[CH:20][CH:19]=3)[CH:16]=2)[C:9](=[O:13])[N:10]([CH3:12])[N:11]=1>C(O)C>[CH3:12][N:10]1[C:9](=[O:13])[C:8]2=[CH:14][N:15]([CH2:17][C:18]3[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=[CH:20][CH:19]=3)[CH:16]=[C:7]2[C:6]([NH:4][CH:1]([CH3:3])[CH3:2])=[N:11]1参加物
4
反応条件
- 温度
- 200 °C
実験手順
Isopropylamine (1 ml) was added to a solution of 4-chloro-2,6-dihydro-2-methyl-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazine-1-one (0.095 g) in ethanol (4 ml) and the mixture was heated in a sealed tube at 200° C. for 3 days then at 250° C. for 24 hours. The mixture was evaporated and the residue was purified by column chromatography, eluting with ethyl acetate followed by recrystallisation from ethyl acetate/isohexane to give the title compound (0.013 g).