3-(1,2-dimethyl-1H-imidazol-5-yl)nitrobenzene → 3-(1,2-dimethyl-1H-imidazol-5-yl)aniline
反応式
[CH3:1][N:2]1[C:6]([C:7]2[CH:8]=[C:9]([N+:13]([O-])=O)[CH:10]=[CH:11][CH:12]=2)=[CH:5][N:4]=[C:3]1[CH3:16]>CO.[Pd]>[CH3:1][N:2]1[C:6]([C:7]2[CH:8]=[C:9]([CH:10]=[CH:11][CH:12]=2)[NH2:13])=[CH:5][N:4]=[C:3]1[CH3:16]参加物
4
実験手順
A suspension of 3-(1,2-dimethyl-1H-imidazol-5-yl)nitrobenzene (19.2 g) in methanol (200 ml) was hydrogenated over palladium on carbon (10% w/w, 50% wet, 5 g) under hydrogen atmosphere for 10 hours. After the catalyst was filtered off, the filtrate was evaporated under reduced pressure. The residue was triturated with ethyl acetate and diisopropyl ether to give 3-(1,2-dimethyl-imidazol-5-yl)aniline (14.65 g).
後処理
- filtrationAfter the catalyst was filtered off
- customthe filtrate was evaporated under reduced pressure
- customThe residue was triturated with ethyl acetate and diisopropyl ether
出典と根拠
- ORDレコード
- ord-0eb2a3f57efd4257993c6c8aba6074ae
- 出典データセット
- uspto-grants-2004_08
- 特許番号
- US06770667B1
反応ノート
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