Sodium hydride → 2-(2,6-Dichloro-4-nitro-phenylsulfanyl)-benzothiazole-6-carbonitrile

HRID 1835536ノート

反応式

HRID 1835536 の反応式
[SH:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([C:11]#[N:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.[Cl:13][C:14]1[CH:19]=[C:18]([N+:20]([O-:22])=[O:21])[CH:17]=[C:16]([Cl:23])[C:15]=1Cl.[H-].[Na+]>CN(C=O)C>[Cl:13][C:14]1[CH:19]=[C:18]([N+:20]([O-:22])=[O:21])[CH:17]=[C:16]([Cl:23])[C:15]=1[S:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([C:11]#[N:12])[CH:8]=[CH:7][C:5]=2[N:6]=1

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 883653,4,5-TrichloronitrobenzeneHCID 1785095042-Sulfanylidene-2,3-dihydro-1,3-benzothiazole-6-carbonitrile

生成物 1

HCID 221487332-(2,6-Dichloro-4-nitro-phenylsulfanyl)-benzothiazole-6-carbonitrile収率 99.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The title compound was prepared using the method of example 258, starting with 2-mercapto-benzothiazole-6-carbonitrile (241) (960 mg, 5.0 mmol), 1,2,3-trichloro-5-nitrobenzene (Acros, 1.13 g, 5.0 mmol) and NaH (Aldrich, 60% suspension, 200 mg, 5.0 mmol) in DMF (25 mL). Compound 260 (1.9 g, 99%) was obtained as a yellow solid.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-59f0ed3c0f434bc4b9188bd08ae7f983
出典データセット
uspto-grants-2004_08
特許番号
US06770648B2

反応ノート

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