Pyridine → 1-Methyl-3-[2-(2-hydroxy-1,1-dimethylethyl)-6-nitro-1,2,3,4-tetrahydroquinolin-4-yl]-urea

HRID 1836312

反応式

HRID 1836312 の反応式
[NH2:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[NH:5][CH:4]([C:15]([CH3:19])([CH3:18])[CH2:16][OH:17])[CH2:3]1.CS[N:22]=[C:23]=[O:24].N1C=CC=C[CH:26]=1>>[CH3:26][NH:22][C:23]([NH:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[NH:5][CH:4]([C:15]([CH3:19])([CH3:18])[CH2:16][OH:17])[CH2:3]1)=[O:24]

参加物

4

反応物 3

HCID 1049PyridineHCID 21933440MethylthioisocyanateHCID 234992302-(4-Amino-6-nitro-1,2,3,4-tetrahydroquinolin-2-yl)-2-methylpropan-1-ol

生成物 1

HCID 234992231-Methyl-3-[2-(2-hydroxy-1,1-dimethylethyl)-6-nitro-1,2,3,4-tetrahydroquinolin-4-yl]-urea

実験手順

The compound of Example 22 (50 mg) and 30 mg of methyl thioisocyanate were dissolved in 1 ml of pyridine. After 2 hours of stirring at room temperature, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent; hexane:ethyl acetate=1:2) to obtain 42 mg of the title compound. Its physical properties are shown below.

後処理

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (elution solvent; hexane:ethyl acetate=1:2)

出典と根拠

ORDレコード
ord-5f5fe1c04f1041d3a3b0e8a83a2192bf
出典データセット
uspto-grants-2004_08
特許番号
US06777427B2

関連ノート

読み込み中…