Sodium Hydroxide → HCID 23499547、化合物

HRID 1836424ノート

反応式

HRID 1836424 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9]C)=[O:8])=[C:5]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:4]=1.[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([OH:9])=[O:8])=[C:5]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:4]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 23499548Methyl 4-methoxy-2-(4-fluorophenyl)benzoate

生成物 1

HCID 23499547HCID 23499547、化合物収率 83%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of methyl 4-methoxy-2-(4-fluorophenyl)benzoate (9.8 g.) in methanol (75 ml.) was added 2N aqueous sodium hydroxide solution (45 ml.) and the mixture heated at reflux for 1.5 hours. The reaction was cooled to ambient temperature, filtered and the filtrate concentrated to remove the methanol. The residual aqueous phase was washed with ether, acidified to pH 1 using concentrated hydrochloric acid and extracted with ethyl acetate. The organic extracts were dried and the solvent removed to give 4-methoxy-2-(4-fluorophenyl)benzoic acid (Compound (xxix) in Scheme 3) as a white solid (7.7 g), which was used without further purification.

後処理

  1. temperaturethe mixture heated
  2. temperatureat reflux for 1.5 hours
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated
  5. customto remove the methanol
  6. washThe residual aqueous phase was washed with ether
  7. extractionextracted with ethyl acetate
  8. customThe organic extracts were dried
  9. customthe solvent removed

出典と根拠

ORDレコード
ord-c1fd8b72a35a49d0b0f73706736bb79f
出典データセット
uspto-grants-2004_08
特許番号
US06777438B2

反応ノート

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