Ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate → (4-{3-[(4-Fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid

HRID 1836559ノート

反応式

HRID 1836559 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:12]=[C:13]([CH:30]=[CH:31][C:32]=2[OH:33])[CH2:14][C:15]2[C:27]([CH3:28])=[CH:26][C:18]([O:19][CH2:20][C:21]([O:23]CC)=[O:22])=[CH:17][C:16]=2[CH3:29])(=[O:10])=[O:9])=[CH:4][CH:3]=1>C(O)C.[OH-].[Na+]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([C:11]2[CH:12]=[C:13]([CH:30]=[CH:31][C:32]=2[OH:33])[CH2:14][C:15]2[C:27]([CH3:28])=[CH:26][C:18]([O:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][C:16]=2[CH3:29])(=[O:10])=[O:9])=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 86588309Ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate

生成物 1

HCID 9803511(4-{3-[(4-Fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid

試薬・触媒・溶媒 2

HCID 14798Sodium Hydroxide触媒HCID 702Ethanol溶媒

実験手順

37 mg (0.08 mmol) of ethyl (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetate (Example 1) are dissolved in 1 ml of ethanol, and a few drops of 1 N aqueous sodium hydroxide solution are added. The mixture is stirred at room temperature for thirty minutes and the solvent is then removed under reduced pressure. Water is added to the residue, and the mixture is extracted three times with ethyl acetate. The combined organic phases are dried with sodium sulphate and concentrated. This gives 32 mg (90% of theory) of (4-{3-[(4-fluorophenyl)sulphonyl]-4-hydroxybenzyl}-3,5-dimethylphenoxy)acetic acid.

後処理

  1. customthe solvent is then removed under reduced pressure
  2. additionWater is added to the residue
  3. extractionthe mixture is extracted three times with ethyl acetate
  4. dry with materialThe combined organic phases are dried with sodium sulphate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-17fe19d775f84c98ac3cd31597ce7ec0
出典データセット
uspto-grants-2004_08
特許番号
US06777442B2

反応ノート

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