2-Bromo-4-(bromomethyl)benzenemethanol → 2-Bromo-4-(bromomethyl)benzaldehyde

HRID 1836750

反応式

HRID 1836750 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][Br:9])[CH:5]=[CH:4][C:3]=1[CH2:10][OH:11]>CCO.CCOC(C)=O.O=[Mn]=O>[Br:9][CH2:8][C:6]1[CH:5]=[CH:4][C:3]([CH:10]=[O:11])=[C:2]([Br:1])[CH:7]=1

参加物

4

反応物 1

HCID 120160372-Bromo-4-(bromomethyl)benzenemethanol

生成物 1

HCID 120160382-Bromo-4-(bromomethyl)benzaldehyde収率 80.6%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 21584252Ethanol ethylacetate溶媒

実験手順

The compound of Step 2 (8 g, 29 mmol, 1 eq) was dissolved in 10% EtOH/EtOAc (300 ml) and 5 eq of MnO2 (12.4 g, 142 mmol) was added every hour for 6 hours. The mixture was filtered through Celite and the solvent was removed under vacuum to give 6.5 g (80%) of the title compound.

後処理

  1. filtrationThe mixture was filtered through Celite
  2. customthe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-12aa8b69e8af4585a6345b4940b0c6b8
出典データセット
uspto-grants-2004_08
特許番号
US06777433B2

関連ノート

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