Methylamine → Methyl(3-phenoxypropyl)amine

HRID 1837268

反応式

HRID 1837268 の反応式
[CH3:1][NH2:2].[O:3]([CH2:10][CH2:11][CH2:12]Br)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>O1CCCC1>[CH3:1][NH:2][CH2:12][CH2:11][CH2:10][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 6329Methylamine2 回HCID 68522Benzene, (3-bromopropoxy)-

生成物 1

HCID 22067856Methyl(3-phenoxypropyl)amine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

3.57 g of methylamine is condensed in a solution of 1.6 ml of 3-phenoxy-propylbromide in 15 ml of anhydrous tetrahydrofuran at −78° C., and it is stirred overnight at room temperature in a pressurized reactor. After the pressurized reactor was opened at −20° C., it is allowed to come to room temperature to allow excess methylamine to evaporate off. Then, the reaction solution is added to saturated sodium chloride solution, extracted with ether, dried on magnesium sulfate and concentrated by evaporation in a vacuum. 2.01 g of methyl-(3-phenoxy-propyl)-amine is obtained as a crude product, which is used without further purification in the next stage.

後処理

  1. customwas opened at −20° C.
  2. customto come to room temperature
  3. customto evaporate off
  4. additionThen, the reaction solution is added to saturated sodium chloride solution
  5. extractionextracted with ether
  6. customdried on magnesium sulfate
  7. concentrationconcentrated by evaporation in a vacuum

出典と根拠

ORDレコード
ord-fc7b3c344a2b4cff8abb4059c487e8b0
出典データセット
uspto-grants-2004_08
特許番号
US06780855B2

関連ノート

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