Ethanol → HCID 12150700、化合物

HRID 1837326ノート

反応式

HRID 1837326 の反応式
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:17])[C:7]([C:12]([O:14]CC)=[O:13])=[CH:8][NH:9]2)=[CH:4][C:3]=1[O:18][CH3:19].[OH-].[Na+].C(O)C.O>C(O)(=O)C>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:17])[C:7]([C:12]([OH:14])=[O:13])=[CH:8][NH:9]2)=[CH:4][C:3]=1[O:18][CH3:19]

参加物

6

反応物 4

HCID 702EthanolHCID 962WaterHCID 14798Sodium HydroxideHCID 12150699Ethyl 7-fluoro-4-hydroxy-6-methoxyquinoline-3-carboxylate

生成物 1

HCID 12150700HCID 12150700、化合物収率 96.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of ethyl 7-fluoro-6-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate (2.2 g, 8.30 mmol) and 13.2 mL of 1 N sodium hydroxide and 40 mL of ethanol is heated at reflux for 3 hours then cooled to room temperature. Water is added and the mixture is acidified with acetic acid. The resultant solid is collected by filtration washing with water to provide 1.90 g of 7-fluoro-6-methoxy-4-oxo-1,4,-dihydro-3-quinolinecarboxylic acid as a white solid, mp 265-267° C.

後処理

  1. temperatureis heated
  2. temperatureat reflux for 3 hours
  3. filtrationThe resultant solid is collected by filtration
  4. washwashing with water

出典と根拠

ORDレコード
ord-978fbb97423d477ab96a2319da53ab11
出典データセット
uspto-grants-2004_08
特許番号
US06780996B2

反応ノート

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