Thionyl Chloride → 4-Chloro-7-fluoroquinoline-3-carbonitrile
反応式
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](O)=[C:7]([C:12]#[N:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>CN(C)C=O>[Cl:17][C:6]1[C:5]2[C:10](=[CH:11][C:2]([F:1])=[CH:3][CH:4]=2)[N:9]=[CH:8][C:7]=1[C:12]#[N:13]参加物
4
実験手順
A mixture of 7-fluoro-4-hydroxyquinoline-3-carbonitrile (2.02 g, 10.7 mmol) and a few drops of N, N-dimethylformamide in 16.0 mL of thionyl chloride is heated at reflux for 1.5 h. The reaction mixture was concentrated in vacuo and toluene (20 mL) is added and the mixture is again concentrated in vacuo to provide 2.18 g of 4-chloro-7-fluoroquinoline-3-carbonitrile as a yellow solid, mp 163-165° C.
後処理
- temperatureis heated
- temperatureat reflux for 1.5 h
- concentrationThe reaction mixture was concentrated in vacuo and toluene (20 mL)
- additionis added
- concentrationthe mixture is again concentrated in vacuo
出典と根拠
- ORDレコード
- ord-674890530a6e46b996d9f71949040f65
- 出典データセット
- uspto-grants-2004_08
- 特許番号
- US06780996B2
反応ノート
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