Sodium Hydroxide → 4-Amino-3-chloro-6-(3,4-dimethylphenyl)-pyridine-2-carboxylic acid

HRID 1837457ノート

反応式

HRID 1837457 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([CH3:15])[CH:9]=2)[N:5]=[C:4]([C:16]([O:18]C)=[O:17])[C:3]=1[Cl:20].[OH-].[Na+]>CO>[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([CH3:15])[CH:9]=2)[N:5]=[C:4]([C:16]([OH:18])=[O:17])[C:3]=1[Cl:20]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 22677522Methyl 4-amino-3-chloro-6-(3,4-dimethylphenyl)pyridine-2-carboxylate

生成物 1

HCID 226773054-Amino-3-chloro-6-(3,4-dimethylphenyl)-pyridine-2-carboxylic acid収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl 4-amino-3-chloro-6-(3,4-dimethylphenyl)pyridine-2-carboxlate (0.9 g, 0.003 mol) was heated at reflux in methanol (50 mL) and 1N sodium hydroxide (75 mL) for two hours. The reaction mixture was partially concentrated and then acidified with concentrated hydrochloric acid. The solid was collected and dried to give 4-amino-3-chloro-6-(3,4-dimethylphenyl)-pyridine-2-carboxylic acid (0.85 g, 0.003 mol), mp 192-4° C.

後処理

  1. concentrationThe reaction mixture was partially concentrated
  2. customThe solid was collected
  3. customdried

出典と根拠

ORDレコード
ord-be64961cd2634ce8a8040f6af51430eb
出典データセット
uspto-grants-2004_08
特許番号
US06784137B2

反応ノート

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