Hydrochloric Acid → 2-Methoxy-3-pyridineacetic acid

HRID 1837703ノート

反応式

HRID 1837703 の反応式
[CH3:1][O:2][C:3]1[C:8]([CH2:9][C:10]#N)=[CH:7][CH:6]=[CH:5][N:4]=1.[OH-:12].[Na+].Cl.C[OH:16]>>[CH3:1][O:2][C:3]1[C:8]([CH2:9][C:10]([OH:16])=[O:12])=[CH:7][CH:6]=[CH:5][N:4]=1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 226785372-(2-Methoxypyridin-3-yl)acetonitrile

生成物 1

HCID 226783192-Methoxy-3-pyridineacetic acid

反応条件

温度
100 °C

実験手順

2.2 g of (2-methoxy-3-pyridyl)methyl cyanide, 35 ml of a 1N aqueous sodium hydroxide and 35 ml of methanol were stirred under heating at 100° C. for 1.5 hours. The mixture was cooled to room temperature, and then, 35 ml of a 5N aqueous hydrochloric acid was added thereto, and the solvent was evaporated. Ethanol was added to the residue and a solid was filtered off. Ethanol was evaporated, and ethanol was added again to the residue and a solid was filtered off. Ethanol was evaporated, to give 2.4 g of white crystals.

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. customthe solvent was evaporated
  3. additionEthanol was added to the residue
  4. filtrationa solid was filtered off
  5. customEthanol was evaporated
  6. additionethanol was added again to the residue
  7. filtrationa solid was filtered off
  8. customEthanol was evaporated

出典と根拠

ORDレコード
ord-35292d471e5d404ea43a0c9dea345650
出典データセット
uspto-grants-2004_08
特許番号
US06784192B2

反応ノート

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