Trimethyl orthoformate → HCID 22678608、化合物

HRID 1837710ノート

反応式

HRID 1837710 の反応式
[Br:1][C:2]1[CH:3]=[C:4](C=O)[C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[CH:12]([O:17][CH3:18])([O:15][CH3:16])OC.O.[O-2].[O-2].[O-2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.[Al+3].[Al+3]>ClCCl>[CH3:18][O:17][CH:12]([O:15][CH3:16])[C:4]1[C:5]([O:8][CH3:9])=[N:6][CH:7]=[C:2]([Br:1])[CH:3]=1

参加物

5

反応物 3

HCID 9005Trimethyl orthoformateHCID 15164035-Bromo-2-methoxypyridine-3-carbaldehydeHCID 71586775Bentonite

生成物 1

HCID 22678608HCID 22678608、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2.58 g of 5-bromo-2-methoxy-3-pyridinecarboxaldehyde was dissolved in 30 ml of dichloromethane, a mixture of 9 ml of trimethyl orthoformate and montmorillonite K-10 (3 g) was added thereto, and the mixture was stirred at room temperature for 2 hours. After filtering the reaction solution, the filtrate was evaporated. To the residue was added ethyl acetate, followed by filtering through alumina. The filtrate was evaporated, to give 3.09 g of the title compound as a yellow oil.

後処理

  1. additionwas added
  2. filtrationAfter filtering the reaction solution
  3. customthe filtrate was evaporated
  4. additionTo the residue was added ethyl acetate
  5. filtrationby filtering through alumina
  6. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-c6c9ebe904244d8a947ff498a75c7d9b
出典データセット
uspto-grants-2004_08
特許番号
US06784192B2

反応ノート

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