Hydrochloric Acid → HCID 22678413、化合物

HRID 1837712ノート

反応式

HRID 1837712 の反応式
C[O:2][CH:3](OC)[C:4]1[C:5]([O:14][CH3:15])=[N:6][CH:7]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:9]=1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH3:13][S:10]([C:8]1[CH:9]=[C:4]([CH:3]=[O:2])[C:5]([O:14][CH3:15])=[N:6][CH:7]=1)(=[O:12])=[O:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 22678645HCID 22678645、化合物

生成物 1

HCID 22678413HCID 22678413、化合物収率 92.9%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

0.81 g of 5-(methylsulfonyl)-2-methoxy-3-pyridinecarboxaldehyde dimethyl acetal was dissolved in 8 ml of acetone, 2 ml of 5N-hydrochloric acid was added thereto, and the mixture was stirred at room temperature for 30 minutes. An aqueous sodium carbonate was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, n-hexane was added to the residue and the resulting product was collected by filtration, to give 0.62 g of the title compound as a white powder.

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated
  5. additionn-hexane was added to the residue
  6. filtrationthe resulting product was collected by filtration

出典と根拠

ORDレコード
ord-00123e3a36254d27ad27ebb74abdefbf
出典データセット
uspto-grants-2004_08
特許番号
US06784192B2

反応ノート

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