Thionyl Chloride → N1-(3-Fluorobenzyl)-2-[1-[2-(2-oxo-1,2-dihydro-3-pyridinyl)ethyl]-2-piperidyl]acetamide
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[CH2:5][NH:6][C:7](=[O:25])[CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][N:10]1[CH2:15][CH2:16][C:17]1[C:18]([O:23]C)=[N:19][CH:20]=[CH:21][CH:22]=1.S(Cl)(Cl)=O>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[CH2:5][NH:6][C:7](=[O:25])[CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][N:10]1[CH2:15][CH2:16][C:17]1[C:18](=[O:23])[NH:19][CH:20]=[CH:21][CH:22]=1参加物
4
実験手順
370 mg of N1-(3-fluorobenzyl)-2-[1-[2-(2-methoxy-3-pyridyl)ethyl]-2-piperidyl]acetamide obtained in Example 177, 0.44 ml of thionyl chloride and 5 ml of ethanol were stirred at 100° C. for 2 hours. The solvent was evaporated, and to the residue was added an aqueous sodium bicarbonate. The mixture was extracted with ethyl acetate, and dried over sodium sulfate. Then the drying agent was filtered off, and the solvent was evaporated, to give 330 mg of white crystals.