3-(6,7,8,9-Tetrahydro-benzo[b]-[1,8]naphthyridin-8-yl)-propionic acid ethyl ester → 3-(1,2,3,4,6,7,8,9-Octahydro-benzo[b]-[1,8]naphthyridin-8-yl)-propionic acid ethyl ester

HRID 1837903ノート

反応式

HRID 1837903 の反応式
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][CH2:6][CH:7]1[CH2:20][C:11]2=[N:12][C:13]3[N:14]=[CH:15][CH:16]=[CH:17][C:18]=3[CH:19]=[C:10]2[CH2:9][CH2:8]1)[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][CH2:6][CH:7]1[CH2:20][C:11]2=[N:12][C:13]3[NH:14][CH2:15][CH2:16][CH2:17][C:18]=3[CH:19]=[C:10]2[CH2:9][CH2:8]1)[CH3:2]

参加物

4

反応物 1

HCID 538305493-(6,7,8,9-Tetrahydro-benzo[b]-[1,8]naphthyridin-8-yl)-propionic acid ethyl ester

生成物 1

HCID 544215783-(1,2,3,4,6,7,8,9-Octahydro-benzo[b]-[1,8]naphthyridin-8-yl)-propionic acid ethyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 14-2 (0.298 g, 1.05 mmol) and Pd on carbon (0.060 g) in ethanol (10 mL) was placed under 1 atm of H2 and stirred for 12 h. The solution was concentrated. The residue was purified by flash chromatography (5% MeOH in CH2Cl2) to give 14-3.

後処理

  1. concentrationThe solution was concentrated
  2. customThe residue was purified by flash chromatography (5% MeOH in CH2Cl2)
  3. customto give 14-3

出典と根拠

ORDレコード
ord-a54d46898c1b4f52a7c6844049b78e16
出典データセット
uspto-grants-2004_08
特許番号
US06784190B2

反応ノート

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