Hydrochloric Acid → 6-(Methylamino)pyridine-3-carboxylic acid
反応式
[N:1]1C=CC=C[CH:2]=1.Cl[C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][N:9]=1.CN.Cl>O>[CH3:2][NH:1][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][N:9]=1参加物
6
実験手順
A 20 ml pyridine solution of 10 g of 6-chloronicotinic acid and 27 ml of 40% methylamine aqueous solution was heated at 150° C. for 24 hours in a sealed tube. After spontaneous cooling to room temperature, this was mixed with water and adjusted to pH 3 with 1 N aqueous hydrochloric acid. The precipitated crystals were collected by filtration to obtain 5.82 g of the title compound as grayish white crystals.
後処理
- filtrationThe precipitated crystals were collected by filtration
出典と根拠
- ORDレコード
- ord-f62f888c96734137889954b0f2443e6b
- 出典データセット
- uspto-grants-2004_01
- 特許番号
- US06673799B1
反応ノート
読み込み中…