Water → 2-(2-Phenyl-benzyl) adipic acid diethylester

HRID 1838515

反応式

HRID 1838515 の反応式
O.[CH2:2]([O:4][C:5](=[O:15])[CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:3].CC[O-].[Na+].[C:20]1([C:26]2[CH:33]=[CH:32][CH:31]=[CH:30][C:27]=2[CH2:28]Br)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1COCC1>[CH2:2]([O:4][C:5](=[O:15])[CH:6]([CH2:28][C:27]1[CH:30]=[CH:31][CH:32]=[CH:33][C:26]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:3]

参加物

6

反応物 4

HCID 962WaterHCID 8844Diethyl AdipateHCID 2633651-(Bromomethyl)-2-phenylbenzeneHCID 2723922Sodium ethoxide

生成物 1

HCID 159139682-(2-Phenyl-benzyl) adipic acid diethylester収率 92%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
60 °C

実験手順

Into a 3 neck flask, equipped with water cooler, were added 43.8 mL (0.22 mol) of diethyladipate and 220 mL THF. 16.3 g (0.24 mol, 1.1 equivalents) of NaOEt were added in small portions, at 20° C., and the reaction mixture was stirred at 60° C. for 16 hours. After cooling to 20° C., 48.6 g (0.20 mol) of 2-phenyl-benzyl bromide was added dropwise. The reaction mixture was stirred at 60° C., for 16 hours, to give 2-(2-phenyl-benzyl) adipic acid diethylester as a viscous oil, in a yield of 92%.

後処理

  1. temperatureAfter cooling to 20° C.
  2. stirringThe reaction mixture was stirred at 60° C., for 16 hours

出典と根拠

ORDレコード
ord-7c6bd9732a114307832c3c289aaf4a9d
出典データセット
uspto-grants-2004_01
特許番号
US06673880B2

関連ノート

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