Methylamine → N-Methyl-2-(p-tolyl)ethanamine

HRID 1838920ノート

反応式

HRID 1838920 の反応式
[CH3:1][NH2:2].S(C1C=CC(C)=CC=1)(O[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)(=O)=O>O1CCCC1>[CH3:1][NH:2][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1

参加物

4

反応物 2

HCID 6329Methylamine2 回HCID 2853862-(4-Methylphenyl)ethyl 4-methylbenzenesulfonate

生成物 1

HCID 22898654N-Methyl-2-(p-tolyl)ethanamine収率 180.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

9.2 g of methylamine are condensed at −20° C. into a solution of 5.8 g of 2-p-tolylethyl tosylate in 15 ml of abs. tetrahydrofuran and the mixture is stirred overnight at room temperature in a pressure vessel. After the pressure vessel has been opened at −20° C., it is allowed to come to room temperature in order to allow excess methylamine to evaporate. The reaction solution is taken up in ether, washed with water and saturated sodium chloride solution, dried over magnesium sulphate and concentrated to dryness in vacuo. 5.39 g of methyl-(2-p-tolylethyl)amine are obtained, which is reacted further as a crude product.

後処理

  1. customhas been opened at −20° C.
  2. customto come to room temperature in order
  3. customto evaporate
  4. washwashed with water and saturated sodium chloride solution
  5. dry with materialdried over magnesium sulphate
  6. concentrationconcentrated to dryness in vacuo

出典と根拠

ORDレコード
ord-b35780ae1b2b434e9cd9b2a11ab538f2
出典データセット
uspto-grants-2004_01
特許番号
US06677324B1

反応ノート

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