Ethyl orthoformate → HCID 22561750、化合物
反応式
C([O:8][CH2:9][CH3:10])(OCC)OCC.[CH3:11][C:12]1[NH:13][CH:14]=[C:15](C)[C:16]=1[C:17]1[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH:22]=1>C(O)(C(F)(F)F)=O>[CH3:14][C:15]1[C:16]([C:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH:18]=2)=[C:12]([CH3:11])[NH:13][C:10]=1[CH:9]=[O:8]参加物
4
反応条件
- 温度
- 0 °C
実験手順
Triethyl orthoformate (6 mL) was added to a solution of 4-(2,4-dimethyl-1H-pyrrol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine (360 mg) in TFA (6 mL) at 0° C. The mixture was stirred at 0° C. for 10 mins and then at rt for 40 mins. The solvent was removed and to the residue was added NaHCO3, extracted with ethyl acetate, dried and concentrated to give 356 mg of 3,5-dimethyl-4-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-pyrrole-2-carbaldehyde.