Hydrogen Bromide → 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

HRID 1840284ノート

反応式

HRID 1840284 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:14]C)=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=1.[BrH:16]>>[BrH:16].[BrH:16].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=1

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 2735754HCID 2735754、化合物

生成物 1

HCID 234479081-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

実験手順

A suspension of 5.5 g of 1-(5-chloro-2-methoxyphenyl)piperazine in 40 mL of 62% hydrobromic acid was stirred at reflux for 30 hours. After cooling to room temperature, the mixture was filtered by suction and the solid was washed on the funnel with acetone affording 6.02 g of the title compound. M.p. >270° C. (ethanol).

後処理

  1. temperatureat reflux for 30 hours
  2. filtrationthe mixture was filtered by suction
  3. washthe solid was washed on the funnel with acetone affording 6.02 g of the title compound

出典と根拠

ORDレコード
ord-7fe13fab2df94984b9a2a5dea6bc4f53
出典データセット
uspto-grants-2004_01
特許番号
US06680319B2

反応ノート

読み込み中…