Acetic Acid → HCID 23445189、化合物

HRID 1841259ノート

反応式

HRID 1841259 の反応式
[F:1][CH:2]([F:11])[O:3][C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7].[CH:12](OCC)(OCC)OCC.[N+:22]([CH2:25]C(OCC)=O)([O-])=O.[C:31]([OH:34])(=[O:33])[CH3:32]>[Fe]>[F:1][CH:2]([F:11])[O:3][C:4]1[CH:5]=[C:6]([N:7]2[CH:12]=[C:32]([C:31]([OH:34])=[O:33])[N:22]=[CH:25]2)[CH:8]=[CH:9][CH:10]=1

参加物

6

反応物 4

HCID 176Acetic Acid2 回HCID 31214Ethyl orthoformate2 回HCID 69379Ethyl nitroacetateHCID 27741103-(Difluoromethoxy)aniline

生成物 1

HCID 23445189HCID 23445189、化合物

試薬・触媒・溶媒 1

HCID 23925Iron触媒

実験手順

Following the general method described in example 234, 3-(difluoromethoxy)aniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a light brown crystalline solid. Mp. 190-191° C. (H2O/dioxane), MS: m/e=253 (M−H−).

出典と根拠

ORDレコード
ord-dce20c1243a545f889fdb4ef959426b5
出典データセット
uspto-grants-2004_01
特許番号
US06683097B2

反応ノート

読み込み中…