HCID 86588089、化合物 → HCID 69823968、化合物

HRID 1841484ノート

反応式

HRID 1841484 の反応式
[CH3:1][O:2][C:3]1[C:12]([N:13]([CH3:34])[C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[C:26]([N+:28]([O-])=O)[CH:25]=[C:24]([N+:31]([O-])=O)[CH:23]=3)[CH2:18][CH2:17]2)=[O:15])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[C:12]([N:13]([CH3:34])[C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[C:26]([NH2:28])[CH:25]=[C:24]([NH2:31])[CH:23]=3)[CH2:18][CH2:17]2)=[O:15])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

参加物

4

反応物 1

HCID 86588089HCID 86588089、化合物

生成物 1

HCID 69823968HCID 69823968、化合物収率 44.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To 1-[(2-methoxyquinoxalin-3-yl)N-methylaminocarbonyl]-4-(3,5-dinitrophenyl)piperazine dissolved in ethanol (30 ml), 10% palladium/carbon (10 mg) was added. The mixture was hydrogenated for 4 hours, and then filtered to remove the 10% palladium/carbon. The filtrate was concentrated and purified by column chromatography to obtain the titled compound.

後処理

  1. filtrationfiltered
  2. customto remove the 10% palladium/carbon
  3. concentrationThe filtrate was concentrated
  4. custompurified by column chromatography

出典と根拠

ORDレコード
ord-ab56bbfeba9e425d9619fed7892240dd
出典データセット
uspto-grants-2004_01
特許番号
US06683184B2

反応ノート

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