1-(2-Methoxyphenyl)piperazine → HCID 86588090、化合物

HRID 1841486

反応式

HRID 1841486 の反応式
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[S:22])OC2C=CC=CC=2)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[CH3:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1.C1CCN2C(=NCCC2)CC1>O1CCCC1>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:34]2[CH2:33][CH2:32][N:31]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[O:24][CH3:23])[CH2:36][CH2:35]2)=[S:22])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

参加物

5

反応物 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 53676590Phenyl N-(2-methoxyquinoxalin-3-yl)thiocarbamate

生成物 1

HCID 86588090HCID 86588090、化合物収率 62.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Phenyl N-(2-methoxyquinoxalin-3-yl)thiocarbamate (215 mg, 0.69 mmol) and 1-(2-methoxyphenyl)piperazine (154 mg, 0.69 mmol) were dissolved in anhydrous tetrahydrofuran (25 ml) and thereto DBU (105 mg, 0.69 mmol) was added. The mixture was stirred at room temperature for 2 hours, concentrated under the reduced pressure to remove the solvent and purified by column chromatography to obtain the titled compound.

後処理

  1. concentrationconcentrated under the reduced pressure
  2. customto remove the solvent
  3. custompurified by column chromatography

出典と根拠

ORDレコード
ord-24815aa18f7d4582b7bea717727f8a32
出典データセット
uspto-grants-2004_01
特許番号
US06683184B2

関連ノート

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