Benzene → 2,6-Dibenzoylpyridine

HRID 1841513

反応式

HRID 1841513 の反応式
[Cl-].[Cl-].[Cl-].[Al+3].Cl[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14](Cl)=[O:15])[N:9]=1)=[O:7].O.[CH:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14](=[O:15])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:9]=1)(=[O:7])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

5

反応物 4

HCID 241BenzeneHCID 962WaterHCID 773352,6-Pyridinedicarbonyl dichlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 3166562,6-Dibenzoylpyridine収率 58%

反応条件

温度
60 °C

実験手順

Aluminium trichloride (5.1 g, 3.18 mmol) was added to a suspension of 2,6-bis(chlorocarbonyl)pyridine (3.7 g, 18 mmol) in 200 ml of benzene. The reaction mixture was heated to 60° C. and kept at that temperature for 4 h and subsequently for 16 h at room temperature. The mixture was poured into water, the organic layer was separated and evaporated to dryness. The residue was dissolved in CH2Cl2 and filtered. Removal of CH2Cl2 in vacuum yielded 3.0 g (58%) of product.

後処理

  1. customthe organic layer was separated
  2. customevaporated to dryness
  3. dissolutionThe residue was dissolved in CH2Cl2
  4. filtrationfiltered
  5. customRemoval of CH2Cl2 in vacuum

出典と根拠

ORDレコード
ord-48fbbee0fd4c4da082c56e3bc44acdc8
出典データセット
uspto-grants-2004_01
特許番号
US06683187B2

関連ノート

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