2-(2-Fluoro-4-nitrophenyl)ethan-1-ol → 2-(4-Amino-2-fluorophenyl)ethanol

HRID 1842955ノート

反応式

HRID 1842955 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][OH:13]>C(O)C.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([CH2:11][CH2:12][OH:13])=[C:2]([F:1])[CH:7]=1

参加物

4

反応物 1

HCID 866721582-(2-Fluoro-4-nitrophenyl)ethan-1-ol

生成物 1

HCID 450906002-(4-Amino-2-fluorophenyl)ethanol収率 89.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a stirred solution of 2-(2-fluoro-4-nitrophenyl)ethanol (200 mg, 0.94 mmol, 1.0 eq) in ethanol (10 mL) was added 10% Pd/C (50 mg) and the mixture was stirred under a H2 gas balloon at RT for 5 h. The reaction mixture was passed through a celite bed and the solvent of the filtrate evaporated to get 2-(4-amino-2-fluorophenyl)ethanol (130 mg, 75%) as a viscous oil (TLC system: EtOAc/PE (1:1), Rf: 0.2).

後処理

  1. customthe solvent of the filtrate evaporated

出典と根拠

ORDレコード
ord-9b2a5642517d49d6990effef8d5a1be0
出典データセット
uspto-grants-2015_02
特許番号
US08946204B2

反応ノート

読み込み中…