2-(2-Fluoro-4-nitrophenyl)-2-methylpropane-1,3-diol → 2-(4-Amino-2-fluorophenyl)-2-methylpropane-1,3-diol

HRID 1842965ノート

反応式

HRID 1842965 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[C:11]([CH3:16])([CH2:14][OH:15])[CH2:12][OH:13]>C(O)C.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([C:11]([CH3:16])([CH2:12][OH:13])[CH2:14][OH:15])=[C:2]([F:1])[CH:7]=1

参加物

4

反応物 1

HCID 708166542-(2-Fluoro-4-nitrophenyl)-2-methylpropane-1,3-diol

生成物 1

HCID 866721622-(4-Amino-2-fluorophenyl)-2-methylpropane-1,3-diol収率 96%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a stirred solution of 2-(2-fluoro-4-nitrophenyl)-2-methylpropane-1,3-diol (100 mg, 0.34 mmol, 1.0 eq) in ethanol was added 10% Pd/C (30 mg) and the mixture was stirred under hydrogen gas balloon atmosphere for 3 h at RT. The reaction mixture was filtered through celite pad and filtrate concentrated under vacuum to get 2-(4-amino-2-fluorophenyl)-2-methylpropane-1,3-diol (65 mg, 76%; TLC system: EtOAc/PE (1:1), Rf: 0.4).

後処理

  1. filtrationThe reaction mixture was filtered through celite pad and filtrate
  2. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-82974dfcdd2a43d6894a91142f83e444
出典データセット
uspto-grants-2015_02
特許番号
US08946204B2

反応ノート

読み込み中…