Methanesulfonyl chloride → N-[(4-bromophenyl)methyl]methanesulfonamide

HRID 1842982ノート

反応式

HRID 1842982 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][CH:3]=1.[CH3:10][S:11](Cl)(=[O:13])=[O:12]>N1C=CC=CC=1.ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][S:11]([CH3:10])(=[O:13])=[O:12])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 775714-Bromobenzylamine

生成物 1

HCID 19027423N-[(4-bromophenyl)methyl]methanesulfonamide収率 95.1%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of (4-bromophenyl)methanamine (500 mg, 2.687 mmol) in pyridine were added methanesulfonyl chloride (0.4 mL, 5.106 mmol) at 0° C. The reaction mixture was stirred for 1 h, then diluted with dichloromethane. The mixture was washed with water. The organic layer was dried (MgSO4) and filtered. The solvent removed in vacuo. The crude product was purified by CC. N-(4-bromobenzyl)methanesulfonamide (675 mg) was obtained (95% yield).

後処理

  1. washThe mixture was washed with water
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. customThe solvent removed in vacuo
  5. customThe crude product was purified by CC

出典と根拠

ORDレコード
ord-35ab45cc85a9468f8169969d6b950cf5
出典データセット
uspto-grants-2015_02
特許番号
US08946204B2

反応ノート

読み込み中…