1-(2-Fluoro-4-nitrophenyl)azetidin-3-ol → 1-(4-Amino-2-fluorophenyl)azetidin-3-ol
反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:14][CH:13]([OH:15])[CH2:12]1>C(O)C.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([N:11]2[CH2:12][CH:13]([OH:15])[CH2:14]2)=[C:2]([F:1])[CH:7]=1参加物
4
実験手順
To a stirred solution of 1-(2-fluoro-4-nitrophenyl)azetidin-3-ol (160 mg, 0.75 mmol, 1.0 eq) in ethanol (10 mL) was added 10% Pd—C (20 mg) and stirred under H2 gas balloon at RT for 5 h. The reaction mixture was passed through celite and concentrated to obtain 1-(4-amino-2-fluorophenyl)azetidin-3-ol (110 mg, 80.0%, viscous oil) (TLC: EtOAc/PE (1:1), Rf: 0.1).
後処理
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-7a5e88cbf7c8406ba9e0a645a65908c7
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946204B2
反応ノート
読み込み中…