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1,2-Dichloroethane → N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(4-cyano-3-fluorophenyl)propanamide

HRID 1843038
ノート
印刷プレビュー

反応式

HRID 1843038 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:13])[C:10]([OH:12])=O)=[CH:5][C:4]=1[F:14])#[N:2].C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl.[Cl:29][C:30]1[CH:31]=[C:32]([N:36]2[C:40]([CH2:41][NH2:42])=[CH:39][C:38]([C:43]([F:46])([F:45])[F:44])=[N:37]2)[CH:33]=[CH:34][CH:35]=1>C(#N)C.O>[Cl:29][C:30]1[CH:31]=[C:32]([N:36]2[C:40]([CH2:41][NH:42][C:10](=[O:12])[CH:9]([C:6]3[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[C:4]([F:14])[CH:5]=3)[CH3:13])=[CH:39][C:38]([C:43]([F:44])([F:45])[F:46])=[N:37]2)[CH:33]=[CH:34][CH:35]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 183667732-(4-Cyano-3-fluorophenyl)propanoic acidHCID 66644230(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

生成物 1

HCID 70816495N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(4-cyano-3-fluorophenyl)propanamide収率 85%

試薬・触媒・溶媒

2
HCID 962Water溶媒HCID 6342Acetonitrile溶媒

実験手順

To a solution of 2-(4-cyano-3-fluorophenyl)propanoic acid (440 mg, 2.278 mmol) in acetonitrile was added HOBt (462 mg, 3.417 mmol), EDC (655 mg, 3.417 mmol) and (1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine (659 mg, 2.392 mmol). The reaction mixture was stirred overnight at room temperature. The mixture was added water and extracted with EtOAc. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The crude product was purified by column chromatography to give pure compound N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(4-cyano-3-fluorophenyl)propanamide (870 mg, 85%).

後処理

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated under reduced pressure
  4. customThe crude product was purified by column chromatography

出典と根拠

ORDレコード
ord-8ee084ef1cc6474ba60c01cdebbc26b3
出典データセット
uspto-grants-2015_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08946204B2

反応ノート

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