Oxalyl chloride → 4-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride

HRID 1843056ノート

反応式

HRID 1843056 の反応式
[F:1][CH:2]([F:19])[C:3]1[C:8]([C:9](O)=[O:10])=[CH:7][N:6]=[C:5]([C:12]([F:18])([F:17])[C:13]([F:16])([F:15])[F:14])[N:4]=1.C(Cl)(=O)C([Cl:23])=O>ClCCl.CN(C)C=O>[F:1][CH:2]([F:19])[C:3]1[C:8]([C:9]([Cl:23])=[O:10])=[CH:7][N:6]=[C:5]([C:12]([F:18])([F:17])[C:13]([F:16])([F:15])[F:14])[N:4]=1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 866600764-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxylic acid

生成物 1

HCID 866600754-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

In 10 ml of dichloromethane, 467 mg of 4-(difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxylic acid are admixed with two drops of N,N-dimethylformamide and cooled to 0° C. Following the dropwise addition of 167 μl of oxalyl chloride, the reaction mixture is stirred at room temperature for three hours and then concentrated by evaporation. This gives the crude product 4-(difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride.

後処理

  1. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-8dd05b45fa9347e3abbf331a6b713599
出典データセット
uspto-grants-2015_02
特許番号
US08946234B2

反応ノート

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