Methyl 3-(2-(tert-butoxy)-2-oxoethoxy)benzoate → [3-(Methoxycarbonyl)phenoxy]acetic acid
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][CH:19]=1)[O:8][CH2:9][C:10]([O:12]C(C)(C)C)=[O:11])=[O:4]>FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1.ClCCl>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][CH:19]=1)[O:8][CH2:9][C:10]([OH:12])=[O:11])=[O:4]参加物
5
実験手順
A solution of t-butyl [3-(methoxycarbonyl)phenoxy]acetate in trifluoroacetic acid (1 kg), anisole (100 mL) and dichloromethane (1 L) was stirred at room temperature for 48 hours. The reaction mixture was concentrated and then the residue was crystallized from diisopropyl ether to obtain the title compound (467 g, 86%) as a white solid.
後処理
- concentrationThe reaction mixture was concentrated
- customthe residue was crystallized from diisopropyl ether
出典と根拠
- ORDレコード
- ord-b38f9c98b5864a879d1efd653c9006d9
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946264B2
反応ノート
読み込み中…