Bromine → HCID 86657727、化合物

HRID 1843734ノート

反応式

HRID 1843734 の反応式
[CH3:1][C:2]1[C:7]([C:8](=[O:10])[CH3:9])=[C:6]([CH3:11])[CH:5]=[C:4]([CH3:12])[N:3]=1.[Br:13]Br>Br.C(O)(=O)C>[BrH:13].[Br:13][CH2:9][C:8]([C:7]1[C:2]([CH3:1])=[N:3][C:4]([CH3:12])=[CH:5][C:6]=1[CH3:11])=[O:10]

参加物

5

反応物 2

HCID 24408BromineHCID 2681241-(2,4,6-Trimethylpyridin-3-yl)ethan-1-one

生成物 1

HCID 86657727HCID 86657727、化合物

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒2 回HCID 260Hydrogen Bromide溶媒

反応条件

温度
70 °C

実験手順

To a solution of 1-(2,4,6-trimethylpyridin-3-yl)ethanone (5.0 g, 30.6 mmol) in 33% HBr in acetic acid solution (10.2 mL) was added bromine (1.57 ml, 30.6 mmol) in acetic acid (10.2 mL) dropwisely. The reaction was stirred at 70° C. for 2.0 h. The solution was cooled to room temperature and washed with ether. The residue was dried under reduced pressure to give 2-bromo-1-(2,4,6-trimethylpyridin-3-yl)ethanone hydrobromide, which was used directly for the next step without further purification.

後処理

  1. temperatureThe solution was cooled to room temperature
  2. washwashed with ether
  3. customThe residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-672a287d3e65443c9d4ed46663c5f559
出典データセット
uspto-grants-2015_02
特許番号
US08946268B2

反応ノート

読み込み中…