Aluminium lithium hydride → 2-(1-Benzothiophen-2-yl)ethan-1-amine

HRID 1843837

反応式

HRID 1843837 の反応式
[N+:1]([CH:4]=[CH:5][C:6]1[S:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[CH:7]=1)([O-])=O.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[S:10]1[C:6]([CH2:5][CH2:4][NH2:1])=[CH:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]1=2

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 668016392-(2-Nitroethenyl)-1-benzothiophene

生成物 1

HCID 126668932-(1-Benzothiophen-2-yl)ethan-1-amine収率 90.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Using analogous reaction conditions and workup as described in Example 1, step 2, 2-(2-nitro-vinyl)-benzo[b]thiophene (I-9a: 2.1 g, 0.010 mol) in dry THF (30 mL) was reacted with LAH (0.81 g, 0.021 mol) in dry THF (20 mL) to afford 1.6 g of the product (87.91% yield).

後処理

  1. customreaction conditions and workup

出典と根拠

ORDレコード
ord-c0f4c3ad00464348aa8058b3b9ba2953
出典データセット
uspto-grants-2015_02
特許番号
US08946260B2

関連ノート

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