Water → 4-(4-Phenyl-benzoyloxy)-2-hydroxy benzoic acid tert-butyl ester

HRID 18439

反応式

HRID 18439 の反応式
[C:1]([O:5][C:6](=[O:15])[C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][C:8]=1[OH:14])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[C:23]1([C:29]2[CH:37]=[CH:36][C:32]([C:33](Cl)=[O:34])=[CH:31][CH:30]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.O>C(Cl)Cl>[C:1]([O:5][C:6](=[O:15])[C:7]1[CH:12]=[CH:11][C:10]([O:13][C:33](=[O:34])[C:32]2[CH:36]=[CH:37][C:29]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:30][CH:31]=2)=[CH:9][C:8]=1[OH:14])([CH3:4])([CH3:2])[CH3:3]

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 841514-Phenylbenzoyl chlorideHCID 217835472,4-Dihydroxy benzoic acid tert-butyl ester

生成物 1

HCID 685855374-(4-Phenyl-benzoyloxy)-2-hydroxy benzoic acid tert-butyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 2,4-dihydroxy benzoic acid tert-butyl ester (420 mg; 2 mmol), triethylamine (202 mg; 2 mmol) and p-phenyl benzoyl chloride (415 mg; 1.9 mmol) in dry CH2Cl2 was stirred under argon atmosphere at room temperature overnight after which time H2O was added. The organic phase was isolated, dried, evaporated to dryness and re-crystallized from 2-propanol to yield 195 mg (25%). MS (LC-MS): 389 (MH−).

後処理

  1. additionwas added
  2. customThe organic phase was isolated
  3. customdried
  4. customevaporated to dryness
  5. customre-crystallized from 2-propanol
  6. customto yield 195 mg (25%)

出典と根拠

ORDレコード
ord-10827724f5dc4d76ba023f47ad4fbfa2
出典データセット
uspto-grants-2010_06
特許番号
US07741352B2

関連ノート

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