Nitromethane → 2-Chloro-1-fluoro-4-(2-nitro-vinyl)-benzene

HRID 1843907ノート

反応式

HRID 1843907 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH:5]=O.[N+:11]([CH3:14])([O-:13])=[O:12].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:14][N+:11]([O-:13])=[O:12])[CH:7]=[CH:8][C:9]=1[F:10]

参加物

5

反応物 3

HCID 6375NitromethaneHCID 14798Sodium HydroxideHCID 5938663-Chloro-4-fluorobenzaldehyde

生成物 1

HCID 668018422-Chloro-1-fluoro-4-(2-nitro-vinyl)-benzene収率 67.05%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Using the same reaction procedure and workup as described in Example 1, 3-chloro-4-fluoro-benzaldehyde (2 g, 12.6135 mmol) in ethanol (63 mL) was reacted with nitro methane (0.68 mL, 12.6135 mmol), 10N NaOH solution (529.7 mL, 13.2441 mmol) at 0° C. for 1 hr to afford 1.7 g of the product (67.05% yield).

後処理

  1. customthe same reaction procedure

出典と根拠

ORDレコード
ord-ac924eeb3c144cfab1e5d61dd08a283a
出典データセット
uspto-grants-2015_02
特許番号
US08946260B2

反応ノート

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