Thionyl Chloride → 2,4-Difluoro-3-methoxybenzoyl chloride
反応式
[F:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([F:13])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:16])=O>C(OCC)(=O)C>[F:1][C:2]1[C:10]([O:11][CH3:12])=[C:9]([F:13])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:16])=[O:5]参加物
4
実験手順
A mixture of 2,4-difluoro-3-methoxybenzoic acid (2.1 g, 11.1 mmol), thionyl chloride (5 mL), and ethyl acetate (30 mL) is refluxed for 4 h. All volatiles are removed in vacuo, and the remaining residue is used directly in the next synthetic step.
後処理
- temperatureis refluxed for 4 h
- customAll volatiles are removed in vacuo
出典と根拠
- ORDレコード
- ord-c3b7e884de4f4ff6b9683aab078298c7
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946422B2
反応ノート
読み込み中…