Chlorosulfonic acid → Methyl 2-[5-bromo-2-(chlorosulfonyl)phenyl]acetate
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:5]=[CH:6][CH:7]=1.[Cl:13][S:14](O)(=[O:16])=[O:15]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:14]([Cl:13])(=[O:16])=[O:15])=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:3]=1参加物
3
実験手順
Methyl 2-(3-bromophenyl)acetate (22 g, 67 mmol) was slowly added into ClSO3H at −10° C. After 1 h, the mixture was warmed up to rt and stirred overnight, diluted slowly with ice water and extracted with EA. The organic layer was washed with water, dried over Na2SO4 and evaporated to give compound P15a (17 g, 54%).
後処理
- extractionextracted with EA
- washThe organic layer was washed with water
- dry with materialdried over Na2SO4
- customevaporated
- customto give compound P15a (17 g, 54%)
出典と根拠
- ORDレコード
- ord-6bdd0a8009b1423cbe5b959f58aecfca
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946446B2
反応ノート
読み込み中…