Oxalyl chloride → HCID 86719134、化合物
反応式
[CH:1]1([CH2:7][N:8]2[C:12]([C:13]3[CH:18]=[C:17]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:16]=[C:15]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH:14]=3)=[CH:11][C:10]([S:27](O)(=[O:29])=[O:28])=[C:9]2[CH3:31])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)(C([Cl:36])=O)=O>C(Cl)Cl>[CH:1]1([CH2:7][N:8]2[C:12]([C:13]3[CH:18]=[C:17]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:16]=[C:15]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH:14]=3)=[CH:11][C:10]([S:27]([Cl:36])(=[O:29])=[O:28])=[C:9]2[CH3:31])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of compound 5c (1.0 g, 2.2 mmol) in CH2Cl2 (10 mL) was added (COCl)2 (0.8 g, 6.6 mmol) dropwise at 0° C. Then this mixture was stirred at 0° C. for 2 h and concentrated to obtain compound 5d (1.0 g, 100%).