Methanol → 6-Cyanobenzo[b]thiophene-2-carboxylic acid

HRID 1845125ノート

反応式

HRID 1845125 の反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[C:9]([C:11]([O:13]C)=[O:12])[S:8][C:7]=2[CH:15]=1)#[N:2].CO.[OH-].[Na+]>O>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[C:9]([C:11]([OH:13])=[O:12])[S:8][C:7]=2[CH:15]=1)#[N:2]

参加物

5

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 11031280Methyl 6-cyanobenzo[b]thiophene-2-carboxylate

生成物 1

HCID 106796506-Cyanobenzo[b]thiophene-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A round bottom flask was charged with methyl 6-cyanobenzo[b]thiophene-2-carboxylate (4.00 g, 17.9 mmol), methanol (130 mL), and sodium hydroxide (23 g, 0.58 mol) in water (200 mL). The reaction was stirred at room temperature for 20 minutes. The reaction was concentrated to half of the volume and acidified with 6 N aq. HCl. The mixture was extracted with CHCl3/i-PrOH (90:10) and the organic phase was concentrated under reduced pressure to get the title compound as a brown solid.

後処理

  1. concentrationThe reaction was concentrated to half of the volume
  2. extractionThe mixture was extracted with CHCl3/i-PrOH (90:10)
  3. concentrationthe organic phase was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-a3fec847502f49579489f56ed53ec9b1
出典データセット
uspto-grants-2015_02
特許番号
US08946439B2

反応ノート

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