Chloride → Methyl 4-chloro-3-(chlorosulfonyl)benzoate

HRID 1845147ノート

反応式

HRID 1845147 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11]([Cl:14])(=[O:13])=[O:12].[Cl-].[CH3:16]O>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:16])=[O:7])=[CH:4][C:3]=1[S:11]([Cl:14])(=[O:12])=[O:13]

参加物

4

反応物 3

HCID 312ChlorideHCID 887MethanolHCID 756134-Chloro-3-(chlorosulphonyl)benzoic acid

生成物 1

HCID 18071846Methyl 4-chloro-3-(chlorosulfonyl)benzoate

実験手順

A round bottom flask was charged with 4-chloro-3-(chlorosulfonyl)benzoic acid (16.0 g, 63.24 mmol) and methanol (100 mL), and thinoyl chloride (9.3 mL, 126.5 mmol) was added slowly at 0° C. The reaction mixture was then heated to reflux for 1.5 hours. The volatiles were removed under reduced pressure, and the residue was diluted with water and extracted with EtOAc. The solvents were removed under reduced pressure to get the title compound as a solid.

後処理

  1. additionwas added slowly at 0° C
  2. temperatureThe reaction mixture was then heated
  3. temperatureto reflux for 1.5 hours
  4. customThe volatiles were removed under reduced pressure
  5. additionthe residue was diluted with water
  6. extractionextracted with EtOAc
  7. customThe solvents were removed under reduced pressure

出典と根拠

ORDレコード
ord-6f0667ae0f104694bb887cc47f59ed7c
出典データセット
uspto-grants-2015_02
特許番号
US08946439B2

反応ノート

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