Diisopropylethylamine → 4'-Methyl-5-(pyrrolidine-1-carbonyl)-N-(quinolin-7-ylmethyl)biphenyl-3-carboxamide

HRID 1845192

反応式

HRID 1845192 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[O:15])[CH:11]=[C:10]([C:21](O)=[O:22])[CH:9]=2)=[CH:4][CH:3]=1.[N:24]1[C:33]2[C:28](=[CH:29][CH:30]=[C:31]([CH2:34][NH2:35])[CH:32]=2)[CH:27]=[CH:26][CH:25]=1.F[P-](F)(F)(F)(F)F.C[N+](C)=C(N(C)C)ON1C2N=CC=CC=2N=N1.C(N(CC)C(C)C)(C)C>CN(C)C=O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[C:12]([C:14]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[O:15])[CH:11]=[C:10]([C:21]([NH:35][CH2:34][C:31]3[CH:32]=[C:33]4[C:28]([CH:27]=[CH:26][CH:25]=[N:24]4)=[CH:29][CH:30]=3)=[O:22])[CH:9]=2)=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 17904490Quinolin-7-ylmethanamineHCID 581879754'-Methyl-5-(pyrrolidine-1-carbonyl)biphenyl-3-carboxylic acid

生成物 1

HCID 581879604'-Methyl-5-(pyrrolidine-1-carbonyl)-N-(quinolin-7-ylmethyl)biphenyl-3-carboxamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
50 °C

実験手順

To a solution of 4′-methyl-5-(pyrrolidine-1-carbonyl)biphenyl-3-carboxylic acid (17 mg, 0.055 mmol) in N,N-dimethylformamide (0.5 mL) were added quinolin-7-ylmethanamine (34 mg, 0.22 mmol) (WO 2008/130481), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (80 mg, 0.21 mmol) and N,N-diisopropylethylamine (80 μL, 0.46 mmol). The reaction mixture was stirred at 50° C. for 16 hours. LC-MS indicated the reaction was complete. The reaction mixture was purified by preparative HPLC to afford the titile compound.

後処理

  1. customThe reaction mixture was purified by preparative HPLC
  2. customto afford the titile compound

出典と根拠

ORDレコード
ord-72a7f77af4c14f0c8ac195600c1d6d12
出典データセット
uspto-grants-2015_02
特許番号
US08946439B2

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