Sodium borohydride → HCID 58941864、化合物

HRID 1845765ノート

反応式

HRID 1845765 の反応式
[CH:1]([C:3]1[S:7][N:6]=[N:5][C:4]=1[C:8]([O:10][CH3:11])=[O:9])=[O:2].[BH4-].[Na+]>C(O)C>[OH:2][CH2:1][C:3]1[S:7][N:6]=[N:5][C:4]=1[C:8]([O:10][CH3:11])=[O:9]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 14913987Methyl 5-formyl-1,2,3-thiadiazole-4-carboxylate

生成物 1

HCID 58941864HCID 58941864、化合物収率 75.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Methyl 5-formyl-1,2,3-thiadiazole-4-carboxylate (460.0 mg, 0.0026 mol) was dissolved in ethanol (40 mL) and sodium tetrahydroborate (50 mg, 0.0013 mol) was added at 0° C. The orange solution was allowed to warm to room temp and was stirred for 30 minutes. The reaction was quenched with acetic acid and then purified by preparative LCMS to give the desired product (340 mg, 73%). MF=C5H6N2O3S; LCMS calculated for C5H7N2O3S (M+H)+: m/z=175.1.

後処理

  1. customThe reaction was quenched with acetic acid
  2. custompurified by preparative LCMS

出典と根拠

ORDレコード
ord-ceb0db0a39914b0abf254b7db8c75fd0
出典データセット
uspto-grants-2015_02
特許番号
US08951536B2

反応ノート

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