Hydrochloric Acid → 1-(2-Aminopyrimidin-4-yl)ethan-1-one
反応式
C[O:2][C:3]([C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH2:13])[N:8]=1)(OC)[CH3:4].Cl>O1CCCC1>[NH2:13][C:9]1[N:8]=[C:7]([C:3](=[O:2])[CH3:4])[CH:12]=[CH:11][N:10]=1参加物
4
実験手順
To a stirred solution of 4-(1,1-dimethoxyethyl)pyrimidin-2-amine (2a) (180 g) in tetrahydrofuran (2 L) was added 2M hydrochloric acid solution (980 mL) and stirring continued at room temperature overnight. Most of the solvent was removed in vacuo and remaining aqueous solution was poured into an aqueous saturated sodium hydrogen carbonate solution. The sandy coloured precipitate was filtered off and dried in vacuo at 40° C. to give the title compound (112 g).
後処理
- customMost of the solvent was removed in vacuo
- additionwas poured into an aqueous saturated sodium hydrogen carbonate solution
- filtrationThe sandy coloured precipitate was filtered off
- customdried in vacuo at 40° C.
出典と根拠
- ORDレコード
- ord-7be1c8cddcd04102a2e8421fe63470c4
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952001B2
反応ノート
読み込み中…