Ammonium Chloride → 1-(2-Aminopyrimidin-4-yl)ethanol
反応式
[NH2:1][C:2]1[N:7]=[C:6]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:4][N:3]=1.[BH4-].[Na+].[Cl-].[NH4+]>CO>[NH2:1][C:2]1[N:7]=[C:6]([CH:8]([OH:10])[CH3:9])[CH:5]=[CH:4][N:3]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
1-(2-aminopyrimidin-4-yl)ethanone (Compound 3a) (0.5 g) was dissolved in 50 mL methanol and cooled to 0° C. Sodium borohydride (0.138 g) was added portion wise and the mixture was stirred for 16 hours at room temperature. Saturated ammonium chloride solution (20 mL) was added and this mixture was extracted twice with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate and evaporated to give the title compound (270 mg) as a colourless oil that solidified on standing.
後処理
- extractionthis mixture was extracted twice with ethyl acetate
- washThe combined organic layers were washed with brine
- dry with materialdried over sodium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-d4e5eedf93cc4a08aed9cd57ee5105c9
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952001B2
反応ノート
読み込み中…